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Inhibitors of Cell Cycle Kinases: Recent Advances and Future Prospects as Cancer Therapeutics

1 Jan 2012

Abstract excerpt

The cell cycle is a tightly regulated series of events that governs cell replication and division. Deregulation of cell cycle kinases, e.g., cyclin-dependent kinases (CDKs), can initiate a hyper-proliferative cell phenotype and cause genomic instability, thus facilitating malignant transformation. Pharmacological agents targeting CDKs have been developed as potential anti-cancer agents for over 20 years, evolving...

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PMID: 22471707
DOI: 10.1615/critrevoncog.v17.i2.40

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