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CDK7 Inhibitors in Cancer Therapy: The Sweet Smell of Success?

9 Mar 2020

Abstract excerpt

Cyclin-dependent kinase (CDK) 7 has a unique functional repertoire by virtue of its dual role in transcription and cell cycle progression. Whereas CDK7 is ubiquitously expressed in various types of cancer, its downregulation leads to reduced cell proliferation. Importantly, it is now agreed that targeting transcription selectively limits the synthesis of mRNAs involved in tumor growth without causing an outage of...

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PMID: 32150405
DOI: 10.1021/acs.jmedchem.9b01985

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