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Targeting Cell Division Cycle 7 Kinase: A New Approach for Cancer Therapy

21 Jul 2010

Abstract excerpt

The cell division cycle 7 (Cdc7) is a serine-threonine kinase, originally discovered in budding yeast, required to initiate DNA replication. Human Cdc7 phosphorylates the minichromosome maintenance protein 2 (Mcm2), a component of the DNA replicative helicase needed for genome duplication. Inhibition of Cdc7 in cancer cells impairs progression through S phase, inducing a p53-independent apoptotic cell death,...

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PMID: 20647475
DOI: 10.1158/1078-0432.ccr-10-0185

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