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Article

Diagnosing recipient- vs. donor-derived posttransplant myelodysplastic neoplasm via targeted single-cell mutational profiling.

Med (New York, N.Y.) - 11 Apr 2025

Ihlow Jana, Penter Livius, Vuong Lam Giang, Bischoff Philip, Obermayer Benedikt, Trinks Alexandra, Blau Olga, Behnke Anke, Conrad Thomas, Morkel Markus, Wu Catherine J, Westermann Jörg, Bullinger Lars, von Brünneck Ann-Christin, Blüthgen Nils, Horst David, Praktiknjo Samantha D

Abstract excerpt

BACKGROUND: Distinguishing donor- vs. recipient-derived myelodysplastic neoplasm (MDS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is challenging and has direct therapeutical implications. METHODS: Here, we took a translational approach that we used in addition to conventional diagnostic techniques to resolve the origin of MDS in a 38-year-old patient with acquired aplastic anemia and...

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PMID: 39644889
DOI: 10.1016/j.medj.2024.11.001

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