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The evolution of preclinical models for myelodysplastic neoplasms

23 Feb 2024

Abstract excerpt

Myelodysplastic Neoplasms (MDS) are a group of clonal disorders characterized by ineffective hematopoiesis and morphologic dysplasia. Clinical manifestations of MDS vary widely and are dictated in large part by a range of genetic aberrations. The lack of robust in vitro models for MDS has limited the ability to conduct high throughput drug screens, which in turn has hampered the development of novel therapies for...

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PMID: 38396286
DOI: 10.1038/s41375-024-02181-2

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