Article

Discovery of dihydroxy-enone–type protein-bound ceramides as the dominant type in human stratum corneum

2026-04-10

Abstract excerpt

Protein-bound ceramides are a specialized subclass of ceramides that are essential for skin barrier function, and their defective formation leads to severe skin disorder ichthyosis. Despite their biological importance, the precise molecular structures of protein-bound ceramides have remained incompletely defined, largely due to the technical challenges arising from their unique covalent linkage between lipid and p...

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Literature Corpus work: 3e0ce27b-164f-5053-a090-1e770bf03189
DOI: 10.64898/2026.04.08.717327

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