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Article

Elucidation of the Synthetic Mechanism of Acylceramide, an Essential Lipid for Skin Barrier Function.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 1 Jan 2017

Ohno Yusuke

Abstract excerpt

The primary function of the skin is to act as a permeability barrier that prevents water loss from inside the body and external invasion such as by pathogens, harmful substances, and allergens. Lipids play a critical role in skin barrier formation by forming multi-lamellar structures in the stratum corneum, the outermost cell layer of the epidermis. Ceramide, the backbone of sphingolipids, accounts for more than...

Read the complete abstract on PubMed

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Share to Cell Membrane Permeability
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermal Cells

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Source

Identifiers

PMID: 28966260
DOI: 10.1248/yakushi.17-00126

Genes

PNPLA1
CERS3
ELOVL1
ELOVL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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