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Article

Comprehensive stratum corneum ceramide profiling reveals reduced acylceramides in ichthyosis patient with CERS3 mutations.

The Journal of dermatology - 1 Apr 2021

Yamamoto Moe, Sassa Takayuki, Kyono Yuki, Uemura Hiroyasu, Kugo Masaaki, Hayashi Hideki, Imai Yasutomo, Yamanishi Kiyofumi, Kihara Akio

Abstract excerpt

The stratum corneum (SC) of the epidermis acts as a skin permeability barrier, and abnormalities in SC formation lead to several skin disorders. Lipids, especially the epidermis-specific ceramide classes ω-O-acylceramides (acylceramides) and protein-bound ceramides, are essential for skin barrier formation. Ceramide synthase 3 (CERS3) is involved in the synthesis of acylceramides and protein-bound ceramides, and...

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Source

Identifiers

PMID: 33492757
DOI: 10.1111/1346-8138.15725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Comprehensive stratum corneum ceramide profiling reveals reduced acylceramides in ichthyosis patient with CERS3 mutations.PMID 33492757Read ↗

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Autosomal recessive congenital ichthyosis: CERS3 mutations identified by a next generation sequencing panel targeting ichthyosis genes.Semantic proximity Read ↗

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