Article
Unbound Corneocyte Lipid Envelopes in 12R-Lipoxygenase Deficiency Support a Specific Role in Lipid-Protein Cross-Linking.
The American journal of pathology - 1 May 2021
Meyer Jason M, Crumrine Debra, Schneider Holm, Dick Angela, Schmuth Matthias, Gruber Robert, Radner Franz P W, Grond Susanne, Wakefield Joan S, Mauro Theodora M, Elias Peter M
Abstract excerpt
Loss-of-function mutations in arachidonate lipoxygenase 12B (ALOX12B) are an important cause of autosomal recessive congenital ichthyosis (ARCI). 12R-lipoxygenase (12R-LOX), the protein product of ALOX12B, has been proposed to covalently bind the corneocyte lipid envelope (CLE) to the proteinaceous corneocyte envelope, thereby providing a scaffold for the assembly of barrier-providing, mature lipid lamellae. To...
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