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Article

SDR9C7 plays an essential role in skin barrier function by dehydrogenating acylceramide for covalent attachment to proteins.

Journal of dermatological science - 1 May 2020

Takeichi Takuya

Abstract excerpt

Among the components of the barrier structure of the stratum corneum in human skin, the corneocyte lipid envelope (CLE) is extremely important for the skin barrier. The importance of the CLE and esterified ω-hydroxy sphingosine (CerEOS), its main precursor, has been suggested from the fact that mutations in a number of genes involved in CerEOS synthesis and CLE formation have been identified as genetic causes of...

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Ceramides
Esterification
Ichthyosis
Lipid Metabolism
Mice
Oxidoreductases

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PMID: 32305239
DOI: 10.1016/j.jdermsci.2020.03.005

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