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Article

RNA as the stone guest of protein aggregation

14 Oct 2020

Abstract excerpt

The study of prions as infectious aggregates dates several decades. From its original formulation, the definition of a prion has progressively changed to the point that many aggregation-prone proteins are now considered bona fide prions. RNA molecules, not included in the original 'protein-only hypothesis', are also being recognized as important factors contributing to the 'prion behaviour', that implies the...

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PMID: 33068411
DOI: 10.1093/nar/gkaa822

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