Article
Pyrimidine RNA Homopolymers Promote Amyloid Formation of a Tau Fragment from the Microtubule-Binding Domain.
The journal of physical chemistry. B - 5 Feb 2026
Karim Md Raza Ul, Haque Seymour, Islam Majedul, Higgins Cynthia, Selim Mohammed, Sardar Md Nazmul, Du Deguo
Abstract excerpt
Abnormal aggregation of microtubule-associated protein tau into β-sheet-rich fibrils is a hallmark feature of Alzheimer's disease and other tauopathies. The pathogenic P301L mutation within the microtubule-binding domain of tau promotes tau filament formation; however, the molecular mechanisms by which intracellular RNAs regulate this aggregation process remain not fully understood. Here, we investigated the...
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