Article

ABL1 Kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in multiple myeloma

2022-05-13

Abstract excerpt

Genomic instability contributes to cancer progression and is at least partly due to dysregulated homologous recombination. Here, we show that an elevated level of ABL1 kinase overactivates the HR pathway and causes genomic instability in multiple myeloma (MM) cells. Inhibiting ABL1 with either shRNA or a pharmacological inhibitor (nilotinib) inhibits HR activity, reduces genomic instability, and slows MM cell grow...

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Literature Corpus work: 3de35b1e-8d7a-56c2-95a2-25146431bfa5
DOI: 10.1101/2022.05.12.491727

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