Article
Mechanisms and Clinical Applications of Genome Instability in Multiple Myeloma.
BioMed research international - 1 Jan 2015
Cagnetta Antonia, Lovera Davide, Grasso Raffaella, Colombo Nicoletta, Canepa Letizia, Ballerini Filippo, Calvio Marino, Miglino Maurizio, Gobbi Marco, Lemoli Roberto, Cea Michele
Abstract excerpt
Ongoing genomic instability represents a hallmark of multiple myeloma (MM) cells, which manifests largely as whole chromosome- or translocation-based aneuploidy. Importantly, although it supports tumorigenesis, progression and, response to treatment in MM patients, it remains one of the least understood components of malignant transformation in terms of molecular basis. Therefore these aspects make the...
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