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Article

DNA Damage Response in Multiple Myeloma: The Role of the Tumor Microenvironment

28 Jan 2021

Abstract excerpt

Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by genomic instability. MM cells present various forms of genetic instability, including chromosomal instability, microsatellite instability, and base-pair alterations, as well as changes in chromosome number. The tumor microenvironment and an abnormal DNA repair function affect genetic instability in this disease. In addition, states of...

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PMID: 33525741
DOI: 10.3390/cancers13030504

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