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Article

Exploiting MYC-induced PARPness to target genomic instability in multiple myeloma

20 Feb 2020

Abstract excerpt

Multiple Myeloma (MM) is a hematologic malignancy strongly characterized by genomic instability, which promotes disease progression and drug resistance. Since we previously demonstrated that LIG3-dependent repair is involved in the genomic instability, drug resistance and survival of MM cells, we here investigated the biological relevance of PARP1, a driver component of Alternative-Non Homologous End Joining...

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PMID: 32079692
DOI: 10.3324/haematol.2019.240713

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