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Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma

1 May 2024

Abstract excerpt

Multiple myeloma (MM) remains an incurable hematological malignancy demanding innovative therapeutic strategies. Targeting MYC, the notorious yet traditionally undruggable oncogene, presents an appealing avenue. Here, using a genome-scale CRISPR-Cas9 screen, we identify the WNK lysine-deficient protein kinase 1 (WNK1) as a regulator of MYC expression in MM cells. Genetic and pharmacological inhibition of WNK1...

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PMID: 38722741
DOI: 10.1016/j.celrep.2024.114211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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