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Understanding DNA Damage Response and DNA Repair in Multiple Myeloma

17 Aug 2023

Abstract excerpt

Multiple myeloma (MM) is a plasma cell malignancy characterized by several genetic abnormalities, including chromosomal translocations, genomic deletions and gains, and point mutations. DNA damage response (DDR) and DNA repair mechanisms are altered in MM to allow for tumor development, progression, and resistance to therapies. Damaged DNA rarely induces an apoptotic response, given the presence of...

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PMID: 37627183
DOI: 10.3390/cancers15164155

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