Article

Accurate protein stability predictions from homology models

2022-07-13

Abstract excerpt

Calculating changes in protein stability (ΔΔG) has been shown to be central for predicting the consequences of single amino acid substitutions in protein engineering as well as interpretation of genomic variants for disease risk. Structure-based calculations are considered most accurate, however the tools used to calculate ΔΔGs have been developed on experimentally resolved structures. Extending those calculations...

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Literature Corpus work: 7c76df4d-dc18-55ad-8674-4e3b277dfe8b
DOI: 10.1101/2022.07.12.499700

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