Article

Microfluidic Co-Culture for Modeling Human Joint Inflammation in Osteoarthritis Research

2025-01-29

Abstract excerpt

Here we present a microfluidic model that allows for co-culture of human osteoblasts, chondrocytes, fibroblasts, and macrophages of both quiescent (M0) and pro-inflammatory (M1) phenotypes, maintaining initial viability of each cell type at 24 h of co-culture. We established healthy (M0-based) and diseased (M1-based) joint models within this system. An established disease model based on supplementation of IFN-γ an...

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Literature Corpus work: 54468d8c-3d24-5ced-81a1-c91e42a0b2ce
DOI: 10.1101/2025.01.27.635089

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