Article

Metabolomic Phenotypes Reflect Patient Sex and Injury Status: A Cross-Sectional Analysis of Human Synovial Fluid

2023-02-04

Abstract excerpt

1. <h4>Background</h4> Post-traumatic osteoarthritis (PTOA) is caused by knee injuries like anterior cruciate ligament (ACL) injuries. Often, ACL injuries are accompanied by damage to other tissues and structures within the knee including the meniscus. Both are known to cause PTOA but underlying cellular mechanisms driving disease remain unknown. Aside from injury, patient sex is a prevalent risk factor associate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2015b75a-cdf7-58bc-b2cf-c784e88cf58a
DOI: 10.1101/2023.02.03.527040

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metabolomic Phenotypes Reflect Patient Sex and Injury Status: A Cross-Sectional Analysis of Human Synovial FluidDOI 10.1101/2023.02.03.527040Read

Metabolic phenotypes reflect patient sex and injury status: A cross-sectional analysis of human synovial fluid.Semantic proximity Read

Tissue-specific and spatially dependent metabolic signatures perturbed by injury in skeletally mature male and female miceSemantic proximity Read

Protein Response to ACL Injury in Humans Show Early Cartilage Remodeling and Differences by SexSemantic proximity Read

Characterization of osteoarthritis phenotypes by global metabolomic profiling of human synovial fluidSemantic proximity Read

LC-MS-Based Metabolomics Analysis Revealed Deleterious Effect of Infrapatellar Fat Pad on Articular Chondrocytes of OsteoarthritisSemantic proximity Read

Classification of osteoarthritis phenotypes by metabolomics analysis.Semantic proximity Read

Understanding osteoarthritis pathogenesis: a multiomics system-based approachSemantic proximity Read

Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studiesSemantic proximity Read

Integrative multi-omics analysis reveals molecular landscape associated with chronic lipid accumulation following contusive spinal cord injurySemantic proximity Read

Osteoarthritis and inflammation: a serious disease with overlapping phenotypic patternsSemantic proximity Read

Metabolic features and regulation of the healing cycle—A new model for chronic disease pathogenesis and treatmentSemantic proximity Read

Inhibition of Early Response Genes Prevents Changes in Global Joint Metabolomic Profiles in Mouse Post-Traumatic OsteoarthritisSemantic proximity Read