Article

Computational Design of a Highly-Specific HVEM-Based Inhibitor of LIGHT Protein

2023-10-13

Abstract excerpt

<h4>Motivation</h4> HVEM-LIGHT binding regulates the immune system response in various ways: it co-stimulates T cell proliferation; promotes B cell differentiation and secretion of immunoglobulins; and enhances dendritic cell maturation. Strong and prolonged stimulation of T cells to proliferate causes high levels of IFN– γ , which leads to chronic inflammation and is the reason for various autoimmune diseases....

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Literature Corpus work: 3dd3592c-50ac-5f65-a9f2-adf72c8f7aa0
DOI: 10.1101/2023.10.10.561657

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