Article

A New Model of Heart Failure with Preserved Ejection Fraction Induced by Metabolic Syndrome in Ossabaw Miniature Swine

2025-05-04

Abstract excerpt

<h4>ABSTRACT</h4> A major obstacle to progress in heart failure with preserved ejection fraction (HFpEF) is the paucity of clinically relevant animal models. We developed a large, translationally relevant model in Ossabaw minipigs, which are genetically predisposed to the metabolic syndrome (MetS). Pigs were fed a “Western diet” high in calories, fructose, fat, cholesterol, and salt and received 1-2 deoxy-cortico...

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Literature Corpus work: 3dd197fd-6217-5956-94f3-379b19fea677
DOI: 10.1101/2025.04.29.651284

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