Article
Chronic high-rate pacing induces heart failure with preserved ejection fraction-like phenotype in Ossabaw swine.
Basic research in cardiology - 12 Oct 2022
Tune Johnathan D, Goodwill Adam G, Baker Hana E, Dick Gregory M, Warne Cooper M, Tucker Selina M, Essajee Salman I, Bailey Chastidy A, Klasing Jessica A, Russell Jacob J, McCallinhart Patricia E, Trask Aaron J, Bender Shawn B
Abstract excerpt
The lack of pre-clinical large animal models of heart failure with preserved ejection fraction (HFpEF) remains a growing, yet unmet obstacle to improving understanding of this complex condition. We examined whether chronic cardiometabolic stress in Ossabaw swine, which possess a genetic propensity for obesity and cardiovascular complications, produces an HFpEF-like phenotype. Swine were fed standard chow (lean;...
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