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Article

Cardiac mitochondrial proteome of lean, healthy Ossabaw minipigs with predisposition to metabolic syndrome versus that of Göttingen minipigs.

American journal of physiology. Heart and circulatory physiology - 1 Mar 2026

Eickelmann Chantal, Gedik Nilgün, Lieder Helmut Raphael, Kollipara Laxmikanth, Sickmann Albert, Sturek Michael, Heusch Gerd, Kleinbongard Petra

Abstract excerpt

Ossabaw minipigs differ from other (mini)pig strains by their genetic predisposition to develop full metabolic syndrome and their nonresponsiveness to cardioprotective interventions, even before developing the diseased phenotype. Previous DNA sequencing data revealed differences in a cluster of mitochondrial protein-coding genes between Ossabaw and Göttingen minipigs-a large animal model without such a genetic...

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Identifiers

PMID: 41638602
DOI: 10.1152/ajpheart.00905.2025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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