Expanding antimicrobial chemical space by engineering drug safety

Abstract excerpt

<h4>ABSTRACT</h4> Antibiotic-resistant (AMR) bacterial infections are a major global health threat. Despite the critical need for new antimicrobials, progress is constrained by protracted development timelines, as well as the requirement for chemical novelty to avoid cross-resistance. Although advances in high-throughput screening, genome mining, and machine learning have greatly accelerated antimicrobial discove...

Topics

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• Drug Design
• Anti-Bacterial Agents
• Antimicrobial Peptides and Activities
• Drug Resistance, Bacterial
• Escherichia coli
• Kinetics
• Microbial Sensitivity Tests
• Mutation

Identifiers and source

Literature Corpus work

e30c8cbc-ca54-5e80-abaa-b97f030366a2

DOI

10.1101/2025.10.31.685078