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Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology

18 Oct 2022

Abstract excerpt

The modeling of chimeric antigen receptor (CAR) T cell therapies has been mostly focused on immunodeficient models. However, there are many advantages in studying CAR-T cell biology in an immunocompetent setting. We generated a fully murine CAR targeting CD105 (endoglin), a component of the TGFβ receptor expressed on the surface of certain solid tumors and acute leukemias. CD105-targeted CAR-T cells can be grown...

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PMID: 36275862
DOI: 10.1080/2162402x.2022.2131229

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