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Abnormal signal pathways and tumor heterogeneity in osteosarcoma

9 Feb 2023

Abstract excerpt

BACKGROUND: Osteosarcoma (OS) is the most frequent and aggressive primary malignant sarcoma among adolescents and chemotherapy has not substantially progressed for decades. New insights into OS development and therapeutic strategies are urgently needed. METHODS: We analyzed integrated single-cell transcriptomes, bulk RNA-seq, and microarray data from Gene Expression Omnibus (GEO) datasets. We also used Weighted...

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PMID: 36759884
DOI: 10.1186/s12967-023-03961-7

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