Article
Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma.
Frontiers in endocrinology - 1 Jan 2021
Dijkstra Krijn K, van den Berg José G, Weeber Fleur, van de Haar Joris, Velds Arno, Kaing Sovann, Peters Dennis D G C, Eskens Ferry A L M, de Groot Derk-Jan A, Tesselaar Margot E T, Voest Emile E
Abstract excerpt
Gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) is a poorly understood disease with limited treatment options. A better understanding of this disease would greatly benefit from the availability of representative preclinical models. Here, we present the potential of tumor organoids, three-dimensional cultures of tumor cells, to model GEP-NEC. We established three GEP-NEC organoid lines, originating from...
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