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Discovery of Dihydropyrrol-2-ones as Novel G0/G1-Phase Arresting Agents Inducing Apoptosis

14 Oct 2019

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide A series of dihydropyrrol-2-ones (DHPs) were designed and synthesized via an efficient multicomponent reaction at room temperature for evaluation of their bioactivities against four human cancer lines (MCF-7, RKO, HeLa, and A549) in vitro. Preliminary structure–activity relationship studies showed that R 4 = 3-MeO-4-OH-Ph is a crucial group for increasing...

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PMID: 31656929
DOI: 10.1021/acsomega.9b02543

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