Article
Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells.
Journal of enzyme inhibition and medicinal chemistry - 1 Dec 2020
Aliotta Federica, Nasso Rosarita, Rullo Rosario, Arcucci Alessandro, Avagliano Angelica, Simonetti Martina, Sanità Gennaro, Masullo Mariorosario, Lavecchia Antonio, Ruocco Maria Rosaria, Vendittis Emmanuele De
Abstract excerpt
The dual phosphatases CDC25 are involved in cell cycle regulation and overexpressed in many tumours, including melanoma. CDC25 is a promising target for discovering anticancer drugs, and several studies focussed on characterisation of quinonoid CDC25 inhibitors, frequently causing undesired side toxic effects. Previous work described an optimisation of the inhibition properties by naphthylphenylamine (NPA)...
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