Article

Novel dual inhibitor targeting CDC25 and HDAC for treating triple-negative breast cancer

2024-07-24

Abstract excerpt

<title>Abstract</title> <p>Triple-negative breast cancer (TNBC) poses a significant challenge for treatment due to its aggressive nature and the lack of effective therapies. This study developed dual inhibitors against cell division cycle 25 (CDC25) and histone deacetylases (HDACs) for TNBC treatment. CDC25 phosphatases are crucial for activating cyclin-dependent kinases (CDKs), the master regulators of cell cycl...

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Literature Corpus work: 05c8b00e-aea5-59b8-a6a4-648f5a743698
DOI: 10.21203/rs.3.rs-4661784/v1

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