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Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update

13 Dec 2018

Abstract excerpt

Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S- and M-phases of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is critically associated with tumor growth in multiple cancer types. Although the role of CDK2 in tumorigenesis has been controversial, emerging evidence proposes that selective CDK2 inhibition may provide a therapeutic benefit against...

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PMID: 30543440
DOI: 10.1021/acs.jmedchem.8b01469

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