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Investigational drugs targeting cyclin-dependent kinases for the treatment of cancer: an update on recent findings (2013-2016)

10 Sept 2016

Abstract excerpt

INTRODUCTION: Cell cycle and gene transcription are under the control of cyclin-dependent kinases (CDKs), whose activity depends on the binding with cyclins. Deregulated CDK activities have been reported in a majority of human cancers, representing potential therapeutic targets. AREAS COVERED: This review provides preclinical and clinical (phase I/II) updates of promising therapeutic compounds targeting CDKs...

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PMID: 27606939
DOI: 10.1080/13543784.2016.1234603

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