Article

Combining segmental bulk- and single-cell RNA-sequencing to define the chondrocyte gene expression signature in the murine knee joint

2020-06-15

Abstract excerpt

<h4>Objective</h4> Due to the small size of the murine knee joint, extracting the chondrocyte transcriptome from articular cartilage (AC) is a major technical challenge. In this study, we demonstrate a new and pragmatic approach of combining bulk RNA-sequencing (RNA-seq) and single cell (sc)RNA-seq to address this problem. <h4>Design</h4> We propose a new cutting strategy of the murine femur which produces three...

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Literature Corpus work: 3db504f5-b621-5588-b6c7-45ae355ad405
DOI: 10.1101/2020.06.13.148056

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