Article

Single-cell RNA-sequencing analysis reveals the molecular mechanism of subchondral bone cell heterogeneity in the development of osteoarthritis

2022-09-01

Abstract excerpt

The cellular composition and underlying spatiotemporal transformation processes of subchondral bone in osteoarthritis (OA) remain unknown. Herein, various cell subsets from tibial plateau of patients with OA are identified, and the mechanism of subchondral microstructure alteration is elaborated using single-cell RNA sequencing technique. We identified two novel endothelial cell (EC) populations characterised by e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 049287a2-44ba-5fe8-b857-51ea4ff65d70
DOI: 10.1136/rmdopen-2022-002314

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell RNA-sequencing analysis reveals the molecular mechanism of subchondral bone cell heterogeneity in the development of osteoarthritisDOI 10.1136/rmdopen-2022-002314Read

Single-cell RNA-sequencing analysis reveals the molecular mechanism of subchondral bone cell heterogeneity in the development of osteoarthritisSemantic proximity Read

Single‐cell <scp>RNA</scp> sequencing in osteoarthritisSemantic proximity Read

Single-cell RNA sequencing in orthopedic researchSemantic proximity Read

Identification of cellular heterogeneity and immunogenicity of chondrocytes via single-cell RNA sequencing technique in human osteoarthritisSemantic proximity Read

From cells to clinic: Single-cell transcriptomics shaping the future of orthopedicsSemantic proximity Read

Single-cell RNA-seq analysis reveals the progression of human osteoarthritis.Semantic proximity Read

Single-Cell RNA-Sequencing Reveals the Skeletal Cellular Dynamics in Bone Repair and OsteoporosisSemantic proximity Read

Who drives the progress of osteoarthritis? -The crosstalk between synoviumand meniscus plays an important roleSemantic proximity Read

Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integrationSemantic proximity Read

A systematic dissection of human primary osteoblasts <i>in vivo</i> at single-cell resolutionSemantic proximity Read

Comprehensive analysis on subchondral bone marrow lesions of human osteoarthritis by integrating bulk and single-cell transcriptomesSemantic proximity Read

Single cell transcriptomics identifies a unique adipocyte population that regulates bone marrow environmentSemantic proximity Read