Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

From cells to clinic: Single-cell transcriptomics shaping the future of orthopedics

28 May 2025

Abstract excerpt

Single-cell RNA sequencing (scRNA-seq) technology hold significant potential for advancing orthopedic research. This review examines the impact of ScRNA-seq on the future development of orthopedic research and practice. In the study of osteoarthritis, scRNA-seq can finely characterize the changes in the subsets of chondrocytes and their role in disease progression. In rheumatoid arthritis, this technique reveals...

Source

Identifiers

PMID: 40510239
DOI: 10.1016/j.jot.2025.05.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

From cells to clinic: Single-cell transcriptomics shaping the future of orthopedicsPMID 40510239Read ↗

Single-cell RNA sequencing in orthopedic researchSemantic proximity Read ↗

Single-cell sequencing: New insights for intervertebral disc degenerationSemantic proximity Read ↗

Single‐cell <scp>RNA</scp> sequencing in osteoarthritisSemantic proximity Read ↗

Single-cell sequencing reveals cellular heterogeneity of nucleus pulposus in intervertebral disc degenerationSemantic proximity Read ↗

Identification of cellular heterogeneity and immunogenicity of chondrocytes via single-cell RNA sequencing technique in human osteoarthritisSemantic proximity Read ↗

Single Cell RNA Sequencing in Autoimmune Inflammatory Rheumatic Diseases: Current Applications, Challenges and a Step Toward Precision MedicineSemantic proximity Read ↗

Applications of single-cell RNA sequencing in rheumatoid arthritisSemantic proximity Read ↗

Unraveling immune cell heterogeneity in autoimmune arthritis: insights from single-cell RNA sequencingSemantic proximity Read ↗

Single-cell RNA sequencing reveals the differentiation and regulation of endplate cells in human intervertebral disc degenerationSemantic proximity Read ↗

Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discsSemantic proximity Read ↗

Single-cell RNA-seq analysis reveals that immune cells induce human nucleus pulposus ossification and degenerationSemantic proximity Read ↗

Combining bulk and single-cell RNA-sequencing data to reveal gene expression pattern of chondrocytes in the osteoarthritic kneeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.