Back to search

Article

TNK2/ACK1 Strengthen Influenza A Virus Infection by Blocking Viral Matrix 2 Protein(M2) into Lysosome to Degradation

2021-01-29

Abstract excerpt

<title>Abstract</title> <p>BackgroundTNK2/ACK1, a non-receptor tyrosine kinase, plays critical roles in signalling transduces and trafficking. Our previous genome-wide CRISPR/CAS9 knockout screen revealed that mutant of TNK2 produced more restrict to influenza virus infection. In this study, we aim to illustrate the role of TNK2 for influenza A virus (IAV) replication in human cells.ResultsCRISPR/Cas9-mediated mu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3d9202d7-9ad1-524d-b035-3ad7e1f557eb
DOI
10.21203/rs.3.rs-153964/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
TNK2/ACK1&nbsp;Strengthen Influenza A Virus Infection by Blocking Viral Matrix 2 Protein(M2) into Lysosome to DegradationDOI 10.21203/rs.3.rs-153964/v1
The battle for autophagy between host and influenza A virusSemantic proximity
A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability.Semantic proximity
The nucleoprotein of influenza A virus inhibits the innate immune response by inducing mitophagySemantic proximity
The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus EntrySemantic proximity
RNA-Sequencing-Based Transcriptomic Analysis Reveals a Role for Annexin-A1 in Classical and Influenza A Virus-Induced Autophagy.Semantic proximity
A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host FactorSemantic proximity
Zika virus NS2A protein induces the degradation of KPNA2 (karyopherin subunit alpha 2) via chaperone-mediated autophagy.Semantic proximity
Mammalian cells use the autophagy process to restrict avian influenza virus replicationSemantic proximity
PSMD12-Mediated M1 Ubiquitination of Influenza A Virus at K102 Regulates Viral Replication.Semantic proximity
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagySemantic proximity
Human Annexin A6 Interacts with Influenza A Virus Protein M2 and Negatively Modulates InfectionSemantic proximity
The genetic driver of Acute Necrotizing Encephalopathy, <i>RANBP2</i> , regulates the inflammatory response to Influenza A virus infectionSemantic proximity
Select a neighboring publication to make it the new centre.