Article
Zika virus NS2A protein induces the degradation of KPNA2 (karyopherin subunit alpha 2) via chaperone-mediated autophagy.
Autophagy - 1 Dec 2020
He Jia, Yang Liping, Chang Peixi, Yang Shixing, Lin Shaoli, Tang Qiyi, Wang Xinping, Zhang Yan-Jin
Abstract excerpt
KPNA2/importin-alpha1 (karyopherin subunit alpha 2) is the primary nucleocytoplasmic transporter for some transcription factors to activate cellular proliferation and differentiation. Aberrant increase of KPNA2 level is identified as a prognostic marker in a variety of cancers. Yet, the turnover mechanism of KPNA2 remains unknown. Here, we demonstrate that KPNA2 is degraded via the chaperone-mediated autophagy...
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