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Article

A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability.

Cell host & microbe - 12 Feb 2014

Beale Rupert, Wise Helen, Stuart Amanda, Ravenhill Benjamin J, Digard Paul, Randow Felix

Abstract excerpt

Autophagy recycles cellular components and defends cells against intracellular pathogens. While viruses must evade autophagocytic destruction, some viruses can also subvert autophagy for their own benefit. The ability of influenza A virus (IAV) to evade autophagy depends on the Matrix 2 (M2) ion-channel protein. We show that the cytoplasmic tail of IAV M2 interacts directly with the essential autophagy protein...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24528869
DOI: 10.1016/j.chom.2014.01.006
PMCID: PMC3991421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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