Article
Transcriptome Profiling of Bovine Macrophages Infected by Mycobacterium avium spp. paratuberculosis Depicts Foam Cell and Innate Immune Tolerance Phenotypes.
Frontiers in immunology - 1 Jan 2019
Ariel Olivier, Gendron Daniel, Dudemaine Pier-Luc, Gévry Nicolas, Ibeagha-Awemu Eveline M, Bissonnette Nathalie
Abstract excerpt
Mycobacterium avium spp. paratuberculosis (MAP) is the causative agent of Johne's disease (JD), also known as paratuberculosis, in ruminants. The mechanisms of JD pathogenesis are not fully understood, but it is known that MAP subverts the host immune system by using macrophages as its primary reservoir. MAP infection in macrophages is often studied in healthy cows or experimentally infected calves, but reports...
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