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Article

Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus.

Nature communications - 12 Jan 2023

Jenkins Meredith L, Ranga-Prasad Harish, Parson Matthew A H, Harris Noah J, Rathinaswamy Manoj K, Burke John E

Abstract excerpt

PIK3CA encoding the phosphoinositide 3-kinase (PI3K) p110α catalytic subunit is frequently mutated in cancer, with mutations occurring widely throughout the primary sequence. The full set of mechanisms underlying how PI3Ks are activated by all oncogenic mutations on membranes are unclear. Using a synergy of biochemical assays and hydrogen deuterium exchange mass spectrometry (HDX-MS), we reveal unique regulatory...

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Identifiers

PMID: 36635288
DOI: 10.1038/s41467-023-35789-6
PMCID: PMC9837058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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