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Article

Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα.

Proceedings of the National Academy of Sciences of the United States of America - 16 Nov 2022

Liu Xiao, Zhou Qingtong, Hart Jonathan R, Xu Yingna, Yang Su, Yang Dehua, Vogt Peter K, Wang Ming-Wei

Abstract excerpt

Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that perform multiple and important cellular functions. The protein investigated here belongs to class IA of the PI3Ks; it is a dimer consisting of a catalytic subunit, p110α, and a regulatory subunit, p85α, and is referred to as PI3Kα. The catalytic subunit p110α is frequently mutated in cancer. The mutations induce a gain of function and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36343266
DOI: 10.1073/pnas.2215621119
PMCID: PMC9674216

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