Article

pyHiM, a new open-source, multi-platform software package for spatial genomics based on multiplexed DNA-FISH imaging

2023-09-21

Abstract excerpt

The three-dimensional (3D) nuclear organization of chromatin in eukaryotes plays a crucial role in gene regulation, DNA replication, and DNA damage repair. While genome-wide ensemble methods have enhanced our understanding of chromatin organization, they lack the ability to capture single-cell heterogeneity and preserve spatial information. To overcome these limitations, a new family of imaging-based methods has e...

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Literature Corpus work: 3d7cc430-5e88-5780-a454-3cc611576d31
DOI: 10.1101/2023.09.19.558412

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