Article
The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.
Molecular cell - 21 Sept 2017
Zhao Yan G, Chen Yong, Miao Guangyan, Zhao Hongyu, Qu Wenyan, Li Dongfang, Wang Zheng, Liu Nan, Li Lin, Chen She, Liu Pingsheng, Feng Du, Zhang Hong
Abstract excerpt
During autophagosome formation in mammalian cells, isolation membranes (IMs; autophagosome precursors) dynamically contact the ER. Here, we demonstrated that the ER-localized metazoan-specific autophagy protein EPG-3/VMP1 controls ER-IM contacts. Loss of VMP1 causes stable association of IMs with the ER, thus blocking autophagosome formation. Interaction of WIPI2 with the ULK1/FIP200 complex and PI(3)P...
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