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Article

Multiscale modeling of form and function.

Science (New York, N.Y.) - 10 Apr 2009

Engler Adam J, Humbert Patrick O, Wehrle-Haller Bernhard, Weaver Valerie M

Abstract excerpt

Topobiology posits that morphogenesis is driven by differential adhesive interactions among heterogeneous cell populations. This paradigm has been revised to include force-dependent molecular switches, cell and tissue tension, and reciprocal interactions with the microenvironment. It is now appreciated that tissue development is executed through conserved decision-making modules that operate on multiple length...

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Identifiers

PMID: 19359578
DOI: 10.1126/science.1170107
PMCID: PMC4527531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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