Article

Distinct mutational pattern of T-cell large granular lymphocyte leukemia combined with pure red cell aplasia: Low mutational burden of STAT3

2023-01-12

Abstract excerpt

T-cell large granular lymphocyte leukemia (T-LGL) is often accompanied by pure red cell aplasia (PRCA). A high depth of next generation sequencing (NGS) was used for detection of the mutational profiles in T-LGL alone (n = 25) and T-LGL combined with PRCA (n = 16). Beside STAT3 mutation (41.5%), the frequently mutated genes included KMT2D (17.1%), TERT (12.2%), SUZ12 (9.8%), BCOR (7.3%), DNMT3A (7.3%), and RUNX1 (...

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Literature Corpus work: 3d30a7b2-f556-57ab-b2d2-caddee74c383
DOI: 10.21203/rs.3.rs-2378286/v1

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