STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia

Abstract excerpt

T-cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder and can cooccur in the context of pure red cell aplasia (PRCA). The aim of the current study was to analyze the signal transducer and activator of transcription 3 (STAT3) mutation status and its clinical significance in T-LGLL. We found STAT3 mutations in 21.4% of patients with T-LGLL. High ß2-MG (ß2-microglobulin) levels...

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