Article
Distinct mutational pattern of T-cell large granular lymphocyte leukemia combined with pure red cell aplasia: low mutational burden of STAT3.
Scientific reports - 4 May 2023
Park Sooyong, Yun Jiwon, Choi Sung Yoon, Jeong Dajeong, Gu Ja-Yoon, Lee Jee-Soo, Seong Moon-Woo, Chang Yoon Hwan, Yun Hongseok, Kim Hyun Kyung
Abstract excerpt
T-cell large granular lymphocyte leukemia (T-LGL) is often accompanied by pure red cell aplasia (PRCA). A high depth of next generation sequencing (NGS) was used for detection of the mutational profiles in T-LGL alone (n = 25) and T-LGL combined with PRCA (n = 16). Beside STAT3 mutation (41.5%), the frequently mutated genes included KMT2D (17.1%), TERT (12.2%), SUZ12 (9.8%), BCOR (7.3%), DNMT3A (7.3%), and RUNX1...
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