Article

Hypoxia drives HIF2-dependent macrophage cell cycle entry and susceptibility to lentiviral transduction

2023-12-16

Abstract excerpt

Macrophages play critical roles across health and disease. Low oxygen conditions (hypoxia) have been associated primarily with cell cycle arrest in cultured dividing cells. Macrophages are typically quiescent in G0, though yolk sac and bone marrow derived macrophages frequently proliferate and monocyte-derived tissue macrophages are able to proliferate in response to tissue signals. Here we show that hypoxia (1% o...

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Literature Corpus work: 3d1175c4-f113-5003-aeac-cf19ad83cea5
DOI: 10.1101/2023.12.15.571908

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